Part of the Brain Fuel Restoration Complex, studied for AMPK activation and glucose metabolism.
Berberine HCl is a plant alkaloid widely studied for its role in activating AMPK, an enzyme involved in cellular energy regulation and glucose metabolism.
In Phytomem One, it anchors what the brand calls the "Brain Fuel Restoration Complex," built around the idea that brain cells need efficient glucose uptake to function well — sometimes informally called "Type 3 Diabetes" in some scientific discussion of brain insulin resistance, a real but nuanced concept, not a formal medical diagnosis.
Berberine is one of the more clinically studied ingredients in this formula generally, though most of that research examines blood sugar markers directly rather than cognitive outcomes.